Disease-gene association network
Dataset information
This is a disease-gene association network that contains information on disease-associated genes. Nodes represent genes and diseases and edges represent associations between them.
| Dataset statistics | |
|---|---|
| Nodes | 7813 |
| Disease nodes | 519 |
| Gene nodes | 7294 |
| Edges | 21357 |
| Nodes in largest SCC | 7813 |
| Fraction of nodes in largest SCC | 1.000000 |
| Edges in largest SCC | 21357 |
| Fraction of edges in largest SCC | 1.000000 |
| Diameter (longest shortest path) | 8 |
| 90-percentile effective diameter | 5.435675 |
The information about genes and variants involved in human diseases can be used for different research purposes, including the investigation of molecular mechanisms of species diseases and their comorbidities, the analysis of the properties of disease genes, the generation of hypotheses on drug therapeutic action and drug adverse effects, the validation of computationally predicted disease genes, and the evaluation of text-mining methods performance.
References
- OMIM.org: Online Mendelian Inheritance in Man, an online catalog of human genes and genetic disorders. Amberger, Joanna S., et al. Nucleic Acids Research. 2014.
- The Comparative Toxicogenomics Database: update 2017. Davis, Allan Peter, et al. Nucleic Acids Research. 2016.
- DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants. Pinero, Janet, et al. Nucleic Acids Research. 2016.
- MINER: Gigascale multimodal biological network. Stanford SNAP Group. GitHub Repository. 2017.
Files
| File | Size | Description |
|---|---|---|
| DG-AssocMiner_miner-disease-gene.tsv.gz | 818KB | Disease-gene associations (edgelist) |